Functional annotation of proteins is a fundamental problem in the post‐genomic era. The
recent availability of protein interaction networks for many model species has spurred on the …

The heterogeneity and instability of human tumors hamper straightforward identification of
cancer-causing mutations through genomic approaches alone. Herein we describe a mouse …

Understanding diseases requires identifying the differences between healthy and affected
tissues. Gene expression data have revolutionized the study of diseases by making it …

Paralleling the diversity of genetic and protein activities, pathologic human tissues also
exhibit diverse radiographic features. Here we show that dynamic imaging traits in non …

The analysis of patient blood transcriptional profiles offers a means to investigate the
immunological mechanisms relevant to human diseases on a genome-wide scale. In …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease
associated with substantial morbidity and mortality. The objective of this study was to …

Aging is characterized by specific alterations in gene expression, but their underlying
mechanisms and functional consequences are not well understood. Here we develop a …

Hepatocellular carcinoma (HCC) is a leading cause of death among cirrhotic patients and
has become a major health problem in developed countries. There is an elemental …

Gene duplication and loss is a powerful source of functional innovation. However, the
general principles that govern this process are still largely unknown. With the growing …

Studies employing high-throughput biological techniques have recently contributed to an
improved characterization of human cancers, allowing for novel sub-classification, better …