Omics-based technologies have been largely adopted during this unprecedented global
COVID-19 pandemic, allowing the scientific community to perform research on a large scale …

COVID-19 currently represents one of the major health challenges worldwide. Albeit its
infectious character, with onset affectation mainly at the respiratory track, it is clear that the …

Background Acute respiratory distress syndrome (ARDS) is etiologically and clinically a
heterogeneous disease. Its diagnostic characteristics and subtype classification, and the …

The pathogenesis of multi-organ dysfunction associated with severe acute SARS-CoV-2
infection remains poorly understood. Endothelial damage and microvascular thrombosis …

An integrative multi-modal metabolic phenotyping model was developed to assess the
systemic plasma sequelae of SARS-CoV-2 (rRT-PCR positive) induced COVID-19 disease …

Background A heterogeneous clinical phenotype is a characteristic of coronavirus disease
2019 (COVID‐19). Therefore, investigating biomarkers associated with disease severity is …

Prior evidence indicates the potential central role of the acid sphingomyelinase
(ASM)/ceramide system in the infection of cells with SARS-CoV-2. We conducted a …

The mechanisms driving SARS-CoV-2 susceptibility remain poorly understood, especially
the factors determining why unvaccinated individuals remain uninfected despite high-risk …

With COVID-19 becoming endemic, there is a continuing need to find biomarkers
characterizing the disease and aiding in patient stratification. We studied the relation …

Ischemic cardiovascular and venous thromboembolic events are a frequent cause of death
in severe COVID-19 patients. Platelet activation plays a key role in these complications …