Advances of zebrafish in neurodegenerative disease: from models to drug discovery

X Wang, JB Zhang, KJ He, F Wang… - Frontiers in Pharmacology, 2021 - frontiersin.org
Neurodegenerative disease (NDD), including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which …

The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases

P Panula, YC Chen, M Priyadarshini, H Kudo… - Neurobiology of …, 2010 - Elsevier
Modulatory neurotransmitters which signal through G protein-coupled receptors control
brain functions which deteriorate in degenerative brain diseases. During the past decade …

Zebrafish as a model organism for neurodegenerative disease

K Chia, A Klingseisen, D Sieger… - Frontiers in molecular …, 2022 - frontiersin.org
The zebrafish is increasingly recognized as a model organism for translational research into
human neuropathology. The zebrafish brain exhibits fundamental resemblance with human …

Zebrafish models of human disease: gaining insight into human disease at ZFIN

YM Bradford, S Toro, S Ramachandran, L Ruzicka… - ILAR …, 2017 - academic.oup.com
Abstract The Zebrafish Model Organism Database (ZFIN; https://zfin. org) is the central
resource for genetic, genomic, and phenotypic data for zebrafish (Danio rerio) research …

Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders: a systematic review

RL Vaz, TF Outeiro, JJ Ferreira - Frontiers in neurology, 2018 - frontiersin.org
Movement disorders can be primarily divided into hypokinetic and hyperkinetic. Most of the
hypokinetic syndromes are associated with the neurodegenerative disorder Parkinson's …

Zebrafish embryos as models for embryotoxic and teratological effects of chemicals

L Yang, NY Ho, R Alshut, J Legradi, C Weiss… - Reproductive …, 2009 - Elsevier
The experimental virtues of the zebrafish embryo such as small size, development outside of
the mother, cheap maintenance of the adult made the zebrafish an excellent model for …

Zebrafish assays for drug toxicity screening

AL Rubinstein - Expert opinion on drug metabolism & toxicology, 2006 - Taylor & Francis
Zebrafish are vertebrate organisms that are of growing interest for preclinical drug discovery
applications. Zebrafish embryos develop most of the major organ systems present in …

Zebrafish and medaka: important animal models for human neurodegenerative diseases

J Wang, H Cao - International journal of molecular sciences, 2021 - mdpi.com
Animal models of human neurodegenerative disease have been investigated for several
decades. In recent years, zebrafish (Danio rerio) and medaka (Oryzias latipes) have become …

Modulatory neurotransmitter systems and behavior: towards zebrafish models of neurodegenerative diseases

P Panula, V Sallinen, M Sundvik, J Kolehmainen… - Zebrafish, 2006 - liebertpub.com
The modulatory aminergic neurotransmitters are involved in practically all important
physiological systems in the brain, and many of them are also involved in human central …

Modeling neurodegeneration in zebrafish

Y Xi, S Noble, M Ekker - Current neurology and neuroscience reports, 2011 - Springer
The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the
study of developmental biology and gene function. It also has proven to be a valuable model …