[HTML][HTML] Artificial intelligence for aging and longevity research: Recent advances and perspectives
A Zhavoronkov, P Mamoshina, Q Vanhaelen… - Ageing research …, 2019 - Elsevier
The applications of modern artificial intelligence (AI) algorithms within the field of aging
research offer tremendous opportunities. Aging is an almost universal unifying feature …
research offer tremendous opportunities. Aging is an almost universal unifying feature …
RNA sequencing for research and diagnostics in clinical oncology
Molecular diagnostics is becoming one of the major drivers of personalized oncology. With
hundreds of different approved anticancer drugs and regimens of their administration …
hundreds of different approved anticancer drugs and regimens of their administration …
[HTML][HTML] Converging blockchain and next-generation artificial intelligence technologies to decentralize and accelerate biomedical research and healthcare
P Mamoshina, L Ojomoko, Y Yanovich, A Ostrovski… - Oncotarget, 2018 - ncbi.nlm.nih.gov
The increased availability of data and recent advancements in artificial intelligence present
the unprecedented opportunities in healthcare and major challenges for the patients …
the unprecedented opportunities in healthcare and major challenges for the patients …
Deep learning applications for predicting pharmacological properties of drugs and drug repurposing using transcriptomic data
Deep learning is rapidly advancing many areas of science and technology with multiple
success stories in image, text, voice and video recognition, robotics, and autonomous …
success stories in image, text, voice and video recognition, robotics, and autonomous …
Drug repositioning in glioblastoma: a pathway perspective
SK Tan, A Jermakowicz, AK Mookhtiar… - Frontiers in …, 2018 - frontiersin.org
Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. The current
standard of care is surgical resection, radiation, and chemotherapy treatment, which extends …
standard of care is surgical resection, radiation, and chemotherapy treatment, which extends …
Mathematical and computational modeling in complex biological systems
The biological process and molecular functions involved in the cancer progression remain
difficult to understand for biologists and clinical doctors. Recent developments in high …
difficult to understand for biologists and clinical doctors. Recent developments in high …
[HTML][HTML] Towards natural mimetics of metformin and rapamycin
Aging is now at the forefront of major challenges faced globally, creating an immediate need
for safe, widescale interventions to reduce the burden of chronic disease and extend human …
for safe, widescale interventions to reduce the burden of chronic disease and extend human …
H3K4me3, H3K9ac, H3K27ac, H3K27me3 and H3K9me3 histone tags suggest distinct regulatory evolution of open and condensed chromatin landmarks
Background: Transposons are selfish genetic elements that self-reproduce in host DNA.
They were active during evolutionary history and now occupy almost half of mammalian …
They were active during evolutionary history and now occupy almost half of mammalian …
Molecular pathway activation–new type of biomarkers for tumor morphology and personalized selection of target drugs
Anticancer target drugs (ATDs) specifically bind and inhibit molecular targets that play
important roles in cancer development and progression, being deeply implicated in …
important roles in cancer development and progression, being deeply implicated in …
Algorithmic annotation of functional roles for components of 3,044 human molecular pathways
Current methods of high-throughput molecular and genomic analyses enabled to
reconstruct thousands of human molecular pathways. Knowledge of molecular pathways …
reconstruct thousands of human molecular pathways. Knowledge of molecular pathways …