The incidence of type 2 diabetes (T2D) has been increasing worldwide, and diabetic kidney
disease (DKD) remains one of the leading long-term complications of T2D. Several lines of …

Background Metabolic syndrome and related metabolic disturbances represent a state of
low-grade inflammation, which accelerates insulin resistance, type 2 diabetes (T2D) and …

Cardiorenal syndrome encompasses a spectrum of disorders involving heart and kidney
dysfunction, and sharing common risk factors, such as hypertension and diabetes. Clinical …

Glycogen storage disease XI, also known as Fanconi-Bickel syndrome (FBS), is a rare
autosomal recessive disorder caused by mutations in the SLC2A2 gene that encodes the …

Congestion is a key pathophysiological feature of heart failure (HF) syndrome that drives
most of the clinical manifestations of acute HF and is related with poor quality of life and …

Abstract Sodium glucose cotransporter 2 (SGLT-2) inhibitors are the latest class of
antidiabetic medications. They prevent glucose reabsorption in the proximal convoluted …

Diabetic kidney disease (DKD) is a serious complication of diabetes that can lead to end-
stage kidney disease. Despite its significant impact, most research has concentrated on the …

Diabetic kidney disease (DKD) is a chronic complication of diabetes and the leading cause
of end-stage renal disease (ESRD) worldwide. Currently, there are limited therapeutic drugs …

Pharmacologic inhibition of the sodium-glucose transporter 2 (SGLT2) in the proximal tubule
brings about physiologic changes predicted to both increase and decrease kidney K+ …

Epigallocatechin gallate (EGCG) has been shown to have antihypertensive activity.
However, the role of epigallocatechin gallate (EGCG) in improving vascular function via …