Alzheimer's disease (AD) is characterized by cognitive decline and loss of neurons in
specific brain regions. Recent findings have suggested an involvement of brain-derived …

A better understanding of Alzheimer's disease (AD) and the development of disease
modifying therapies are some of the biggest challenges of the 21st century. One of the core …

Nitric oxide is multifunctional messenger molecule in the brain, playing important roles
including in learning and memory and in regulating the expression of trophic factors that …

Alzheimer's disease (AD) is a neurodegenerative pathology characterized by the presence
of senile plaques and neurofibrillary tangles, accompanied by synaptic and neuronal loss …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
increased deposition of beta-amyloid (Aβ) peptides and progressive cholinergic dysfunction …

Amyloid β, the major constituent of the senile plaques in the brains of patients with
Alzheimer's disease, is cytotoxic to neurons and has a central role in the pathogenesis of the …

Senile plaques composed mainly by β-amyloid (Aβ) protein are one of the pathological
hallmarks of Alzheimer's disease (AD). In vitro, Aβ and its active fragment 25–35 have been …

Amyloid β-peptide (Aβ) plays a critical role in the development of Alzheimer's disease (AD).
Much progress has been made in understanding this age-related neurodegenerative …

In the present study we found that chronic infusion of β-amyloid fragment (25–35) at
nanomolar concentration into rat cerebral ventricle impairs learning and memory. At a …

The deposition of Amyloid β peptide plaques is a pathological hallmark of Alzheimer's
disease (AD). The Aβ (25–35) peptide is regarded as the toxic fragment of full-length Aβ (1 …