Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome

S Vannuccini, VL Clifton, IS Fraser… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND Reproductive disorders and infertility are associated with the risk of
obstetric complications and have a negative impact on pregnancy outcome. Affected …

Uterine fibroids and infertility

D Freytag, V Günther, N Maass, I Alkatout - Diagnostics, 2021 - mdpi.com
Infertility is a disease of the reproductive system defined by the failure to achieve a clinical
pregnancy after 12 months or more of regular unprotected sexual intercourse. Uterine …

Molecular and cellular insights into the development of uterine fibroids

A Machado-Lopez, C Simón, A Mas - International journal of molecular …, 2021 - mdpi.com
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

Pathogenomics of uterine fibroids development

VS Baranov, NS Osinovskaya… - International journal of …, 2019 - mdpi.com
We review recent studies dealing with the molecular genetics and basic results of omics
analysis of uterine leiomyoma (LM)—a common benign muscle tumor of the uterus. Whole …

Hormones and pathogenesis of uterine fibroids

FM Reis, E Bloise, TM Ortiga-Carvalho - Best Practice & Research Clinical …, 2016 - Elsevier
Highlights•Both estradiol and progesterone are essential for uterine fibroid
development.•Ovarian blockade arrests leiomyoma growth, but it has many side …

Uterine fibroids and diet

A Tinelli, M Vinciguerra, A Malvasi, M Andjić… - International journal of …, 2021 - mdpi.com
Uterine myomas or fibroids are the most common benign female tumors of the reproductive
organs, associated with significant morbidity and quality of life impairment. Several …

Progesterone signaling and uterine fibroid pathogenesis; molecular mechanisms and potential therapeutics

M Ali, M Ciebiera, S Vafaei, S Alkhrait, HY Chen… - Cells, 2023 - mdpi.com
Uterine fibroids (UFs) are the most important benign neoplastic threat to women's health
worldwide, with a prevalence of up to 80% in premenopausal women, and can cause heavy …

[HTML][HTML] With the advent of selective progesterone receptor modulators, what is the place of myoma surgery in current practice?

J Donnez, O Donnez, MM Dolmans - Fertility and Sterility, 2014 - Elsevier
Uterine fibroids are the most common benign uterine tumors. This review examines the
different management strategies, involving mainly surgery, and evaluates them in the light of …

Vascular biology of uterine fibroids: connecting fibroids and vascular disorders

GW Kirschen, A AlAshqar, M Miyashita-Ishiwata… - …, 2021 - rep.bioscientifica.com
Fibroids are benign tumors caused by the proliferation of myometrial smooth muscle cells in
the uterus that can lead to symptoms such as abdominal pain, constipation, urinary …

Management of uterine fibroids in pregnancy: recent trends

SG Vitale, F Padula, FA Gulino - Current Opinion in Obstetrics and …, 2015 - journals.lww.com
Myomectomy can increase the rate of pregnancy in women with infertility, attempting to
restore a normal anatomy and reduce uterine contractility and local inflammation associated …