Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide,
but credible estimates from the World Health Organization and the International Agency for …

Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute
and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury …

Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts
and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal …

Macroautophagy/autophagy is known to be important for intracellular quality control in the
lens. GJA8 is a major gap junction protein in vertebrate lenses. Mutations in GJA8 cause …

Diabetes mellitus, a disease that affects nearly 536.6 million people worldwide, is
characterized by the death or dysfunction of insulin-producing beta cells of the pancreas …

Background and Aims Connexins and their cell membrane channels contribute to the control
of cell proliferation and compartmental functions in breast glands and their deregulation is …

Gap junctions (GJs) exhibit a complex modus of assembly and degradation to maintain
balanced intercellular communication (GJIC). Several growth factors, including vascular …

Background Oxidative stress and mitochondrial dysfunction play a significant role in
hepatocarcinogenesis. Mitochondria are source organelle as well as target for free radicals …

Introduction Helicobacter pylori causes, via the influence of several virulence factors,
persistent infection of the stomach, which leads to severe complications. Vacuolating …

Helicobacter pylori (H. pylori) produces vacuolating cytotoxin (VacA), a potent protein toxin,
which is associated with gastric inflammation and ulceration. Recent studies demonstrated …