Recent insights into humoral and cellular immune responses against malaria
Effective immunity to malaria has been clearly demonstrated among individuals naturally
exposed to malaria, and can be induced by experimental infections in animals and humans …
exposed to malaria, and can be induced by experimental infections in animals and humans …
Progress and insights toward an effective placental malaria vaccine
B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …
malaria is progressively acquired during childhood and adults are usually protected against …
Cryo-electron microscopy of IgM-VAR2CSA complex reveals IgM inhibits binding of Plasmodium falciparum to Chondroitin Sulfate A
RR Akhouri, S Goel, U Skoglund - Nature Communications, 2023 - nature.com
Placental malaria is caused by Plasmodium falciparum-infected erythrocytes (IEs) adhering
to chondroitin sulfate proteoglycans in placenta via VAR2CSA-type PfEMP1. Human …
to chondroitin sulfate proteoglycans in placenta via VAR2CSA-type PfEMP1. Human …
Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA
R Ma, T Lian, R Huang, JP Renn, JD Petersen… - Nature …, 2021 - nature.com
Plasmodium falciparum VAR2CSA binds to chondroitin sulfate A (CSA) on the surface of the
syncytiotrophoblast during placental malaria. This interaction facilitates placental …
syncytiotrophoblast during placental malaria. This interaction facilitates placental …
[HTML][HTML] Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies
P Khunrae, M Dahlbäck, MA Nielsen… - Journal of molecular …, 2010 - Elsevier
Plasmodium falciparum malaria remains one of the world's leading causes of human
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …
Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites
A Ghumra, JP Semblat, R Ataide, C Kifude… - PLoS …, 2012 - journals.plos.org
Sequence diversity in pathogen antigens is an obstacle to the development of interventions
against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 …
against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 …
Var2CSA minimal CSA binding region is located within the N-terminal region
A Srivastava, S Gangnard, S Dechavanne, F Amirat… - PloS one, 2011 - journals.plos.org
Var2CSA, a key molecule linked with pregnancy-associated malaria (PAM), causes
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …
Induction of Adhesion-Inhibitory Antibodies against Placental Plasmodium falciparum Parasites by Using Single Domains of VAR2CSA
MA Nielsen, VV Pinto, M Resende… - Infection and …, 2009 - Am Soc Microbiol
In areas of endemicity pregnancy-associated malaria is an important cause of maternal
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …
The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development
L Hviid - Human vaccines, 2010 - Taylor & Francis
There is substantial immuno-epidemiological evidence that the parasite-encoded, so-called
variant surface antigens (VSAs) such as PfEMP1 on the surface of infected erythrocytes (IEs) …
variant surface antigens (VSAs) such as PfEMP1 on the surface of infected erythrocytes (IEs) …
High avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria
VAR2CSA mediates sequestration of Plasmodium falciparum-infected erythrocytes in the
placenta, increasing the risk of poor pregnancy outcomes. Naturally acquired antibodies …
placenta, increasing the risk of poor pregnancy outcomes. Naturally acquired antibodies …