Duchenne muscular dystrophy (DMD) is caused by the lack of functional dystrophin protein.
Improvements in patient care and disease management have slowed down disease …

Duchenne muscular dystrophy is an X-linked disease caused by the absence of functional
dystrophin in the muscle cells. Major advances have led to the development of gene …

As a functional amino acid (AA), L-arginine (Arg) serves not only as a building block of
protein but also as an essential substrate for the synthesis of nitric oxide (NO), creatine …

Our knowledge of the effect of metformin on human health is increasing. In addition to its
ability to improve the control of hyperglycaemia, metformin has been shown to reduce the …

Duchenne muscular dystrophy (DMD) affects 1 in 3500 live male births. To date, there is no
effective cure for DMD, and the identification of novel molecular targets involved in disease …

Duchenne muscular dystrophy (DMD), myotonic dystrophy type 1 (DM1), and spinal
muscular atrophy (SMA) are the most prevalent neuromuscular disorders (NMDs) in children …

Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disease that primarily
affects young males. Patients with DMD are unable to produce dystrophin, a crucial protein …

Despite the full cloning of the Dystrophin cDNA 35 years ago, no effective treatment exists
for the Duchenne Muscular Dystrophy (DMD) patients who have a mutation in this gene …

Metformin is a biguanide, evolved as one of the most widely used medicines. The
applications of this component include but are not limited to reducing blood glucose, weight …

Besides skeletal muscle dysfunction, Duchenne muscular dystrophy (DMD) exhibits a
progressive cardiomyopathy characterized by an impaired calcium (Ca2+) homeostasis and …