Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

The key pathological hallmarks—extracellular plaques and intracellular neurofibrillary
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …

Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …

An international consensus report in 2019 recommended a classification system for limbic-
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …

Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

SVD is the leading cause of VCI and is associated with substantial morbidity. Tackling
cardiovascular risk factors is currently the most effective approach to prevent cognitive …

Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and
contribute to neurodegenerative pathology. Although microglia have been the focus of work …

Cerebral amyloid angiopathy, which is defined by cerebrovascular deposition of amyloid β,
is a common age-related small vessel pathology associated with intracerebral haemorrhage …

SARS-Cov-2 virus has attracted a lot of attention globally, due to the autoimmune and
inflammatory processes that were observed during the development of Covid-19 disease …