The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …

Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Background Baicalin, which is isolated from Radix Scutellariae, possesses strong biological
activities including an anti-inflammation property. Recent studies have shown that the anti …

Ethnopharmacological relevance According to traditional Chinese medicine (TCM) theory
(Yi Xue Zheng Zhuan), the main factors associated with the pathogenesis of depression are …

Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Ethnopharmacological relevance Depression, one of the most common psychiatric
disorders, is the fourth leading cause of long-term disability worldwide. A series of causes …

The gut–microbiota–brain axis is the most important complex and bidirectional pathway
between the gastrointestinal tract and the central nervous system. This study investigated …

Quercetin is a flavonoid compound rich in many natural plants with a wide range of
pharmacological effects and nutritional value. Although previous studies have initially shown …

Hippocampal neurogenesis is known to be related to depressive symptoms. Increasing
evidence indicates that Wnt/β-catenin signaling regulates multiple aspects of adult …

Background The chronic unpredictable mild stress (CUMS) model has long been
considered the best model for exploring the pathophysiological mechanisms underlying …