14-and 15-membered lactone macrolides and their analogues and hybrids: Structure, molecular mechanism of action and biological activity
A Janas, P Przybylski - European journal of medicinal chemistry, 2019 - Elsevier
Abstract Classical macrolides containing 14-or 15-membered aglycone lactone rings are
basic and widely used antibacterial agents in clinical therapy. Macrolides exert antibacterial …
basic and widely used antibacterial agents in clinical therapy. Macrolides exert antibacterial …
Advanced methods for studying structure and interactions of macrolide antibiotics
T Jednačak, I Mikulandra, P Novak - International journal of molecular …, 2020 - mdpi.com
Macrolide antibiotics are macrocyclic compounds that are clinically used and prescribed for
the treatment of upper and lower respiratory tract infections. They inhibit the synthesis of …
the treatment of upper and lower respiratory tract infections. They inhibit the synthesis of …
Discovery of macrozones, new antimicrobial thiosemicarbazone-based azithromycin conjugates: Design, synthesis and in vitro biological evaluation
I Grgičević, I Mikulandra, M Bukvić, M Banjanac… - International journal of …, 2020 - Elsevier
Increasing bacterial resistance to existing antibiotics presents a serious threat to human
health, and new antibacterial agents are desperately needed. Unfortunately, the number of …
health, and new antibacterial agents are desperately needed. Unfortunately, the number of …
Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of …
BZ Fan, H Hiasa, W Lv, S Brody, ZY Yang… - European Journal of …, 2020 - Elsevier
In the search for novel hybrid molecules by fusing two biologically active scaffolds into one
heteromeric chemotype, we found that hybrids of azithromycin and ciprofloxacin/gatifloxacin …
heteromeric chemotype, we found that hybrids of azithromycin and ciprofloxacin/gatifloxacin …
An approach to modify 14-membered lactone macrolide antibiotic scaffolds
A Janas, K Pyta, M Gdaniec… - The Journal of Organic …, 2022 - ACS Publications
A ketolide derivative with (12 R)-configuration was obtained via a novel ketene acetal in
acidic conditions. The structure of this atypical β-keto ketene acetal intermediate within the …
acidic conditions. The structure of this atypical β-keto ketene acetal intermediate within the …
Analyzing atomic scale structural details and nuclear spin dynamics of four macrolide antibiotics: erythromycin, clarithromycin, azithromycin, and roxithromycin
The current investigation centers on elucidating the intricate molecular architecture and
dynamic behavior of four macrolide antibiotics, specifically erythromycin, clarithromycin …
dynamic behavior of four macrolide antibiotics, specifically erythromycin, clarithromycin …
Synthesis and Antibacterial Activity of New N‐Alkylammonium and Carbonate‐Triazole Derivatives within Desosamine of 14‐ and 15‐Membered Lactone Macrolides
Desosamines of azithromycin (AZM) and clarithromycin (CLA) were modified by N‐alkylation
or nucleophilic substitution at the carbonyl/CuAAC sequence. Biological studies revealed a …
or nucleophilic substitution at the carbonyl/CuAAC sequence. Biological studies revealed a …
Rapid structure determination of bioactive 4 ″-tetrahydrofurfuryl macrozone reaction mixture components by LC-SPE/cryo NMR and MS
I Habinovec, I Mikulandra, LE Sekula, J Gašperov… - Molecules, 2021 - mdpi.com
LC-SPE/cryo NMR and MS methodologies have been developed and employed for a rapid
structure determination of 4 ″-tetrahydrofurfuryl macrozone reaction mixture components …
structure determination of 4 ″-tetrahydrofurfuryl macrozone reaction mixture components …
[HTML][HTML] Pharmacochemical aspects of the evolution from erythromycin to neomacrolides, ketolides and neoketolides
O Mahama, C Songuigama - Open Journal of Medicinal Chemistry, 2020 - scirp.org
Antibiotic macrolides are experiencing renewed interest in anti-infective therapy since the
advent of ketolides. This therapeutic class was introduced in order to broaden the narrow …
advent of ketolides. This therapeutic class was introduced in order to broaden the narrow …
Screening of Novel Antimicrobial Diastereomers of Azithromycin–Thiosemicarbazone Conjugates: A Combined LC-SPE/Cryo NMR, MS/MS and Molecular Modeling …
I Habinovec, I Mikulandra, P Pranjić, S Kazazić… - Antibiotics, 2022 - mdpi.com
A well-known class of antibacterials, 14-and 15-membered macrolides are widely
prescribed to treat upper and lower respiratory tract infections. Azithromycin is a 15 …
prescribed to treat upper and lower respiratory tract infections. Azithromycin is a 15 …