Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Mitochondria are fundamental for metabolic homeostasis in all multicellular eukaryotes. In
the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to …

Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ
from those of non-AD individuals. Initial studies revealed structural differences, and …

It has long been recognized that an increase of reactive oxygen species (ROS) can modify
the cell‐signaling proteins and have functional consequences, which successively mediate …

Parkinson's disease (PD) is the second most common neurodegenerative disease. About
2% of the population above the age of 60 is affected by the disease. The pathological …

Mitochondria are essential organelles within the cell where most ATP is produced through
oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are …

The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing
the respiratory tract disease COVID-19 has reached worldwide resonance and a global …

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks
of AD are amyloid plaques [aggregates of amyloid beta (A)] and neurofibrillary tangles …

Ischemic stroke (IS) accounts for more than 80% of the total stroke, which represents the
leading cause of mortality and disability worldwide. Cerebral ischemia/reperfusion injury …