Larvicidal potential of the halogenated sesquiterpene (+)-obtusol, isolated from the alga Laurencia dendroidea J. Agardh (Ceramiales: Rhodomelaceae), against the …

O Salvador-Neto, SA Gomes, AR Soares… - Marine drugs, 2016 - mdpi.com
Dengue is considered a serious public health problem in many tropical regions of the world
including Brazil. At the moment, there is no viable alternative to reduce dengue infections …

In Vitro and In Vivo Activities of 2,3-Diarylsubstituted Quinoxaline Derivatives against Leishmania amazonensis

V Kaplum, J Cogo, DP Sangi… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
Leishmaniasis is endemic in 98 countries and territories worldwide. The therapies available
for leishmaniasis have serious side effects, thus prompting the search for new therapies. The …

Miltefosine increases lipid and protein dynamics in Leishmania amazonensis membranes at concentrations similar to those needed for cytotoxicity activity

RA Moreira, SA Mendanha, KS Fernandes… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Miltefosine (MT) is a membrane-active alkylphospholipid licensed for the topical treatment of
breast cancer skin metastases and the oral treatment of leishmaniasis, although its …

Natural Products from Red Algal Genus Laurencia as Potential Inhibitors of RdRp and nsp15 Enzymes of SARS-CoV-2: An In Silico Perspective

O Pokharkar, H Anumolu, GV Zyryanov… - Microbiology …, 2023 - mdpi.com
The genus Laurencia, a category of marine red algae, is well recognized for producing a
large variety of natural products (NPs) that are both chemically intriguing and structurally …

Reduction of Toxoplasma gondii development due to inhibition of parasite antioxidant enzymes by a dinuclear iron (III) compound

JA Portes, TG Souza, TAT Dos Santos… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular
protozoan that can infect a wide range of vertebrate cells. Here, we describe the cytotoxic …

Novel gallate triphenylphosphonium derivatives with potent antichagasic activity

LA Cortes, L Castro, B Pesce, JD Maya, J Ferreira… - PloS one, 2015 - journals.plos.org
Chagas disease is one of the most neglected tropical diseases in the world, affecting nearly
15 million people, primarily in Latin America. Only two drugs are used for the treatment of …

New ecological role of seaweed secondary metabolites as autotoxic and allelopathic

DB Sudatti, HM Duarte, AR Soares… - Frontiers in Plant …, 2020 - frontiersin.org
Allelopathy and autotoxicity are well-known biological processes in angiosperms but are
very little explored or even unknown in seaweeds. In this study, extract and major pure …

[PDF][PDF] Phytochemical and biological properties of sesquiterpene constituents from the marine red seaweed Laurencia: A review

SM Al-Massarani - Nat. Prod. Chem. Res, 2014 - researchgate.net
Phytochemical and Biological Properties of Sesquiterpene Constituents From the Marine Red
Seaweed Laurencia: A Review Page 1 Volume 2 • Issue 5 • 1000147 Nat Prod Chem Res ISSN …

Antiprotozoal Activity of Benzoylthiourea Derivatives against Trypanosoma cruzi: Insights into Mechanism of Action

PML Pereira, BT Fernandes, VR Dos Santos… - Pathogens, 2023 - mdpi.com
For decades, only two nitroheterocyclic drugs have been used as therapeutic agents for
Chagas disease. However, these drugs present limited effectiveness during the chronic …

Moringa oleifera extract promotes apoptosis-like death in Toxoplasma gondii tachyzoites in vitro

L Nishi, RA da Silva Sanfelice, BT da Silva Bortoleti… - Parasitology, 2021 - cambridge.org
Toxoplasma gondii is the causative agent of toxoplasmosis, and an important problem of
public health. The current treatment for toxoplasmosis is the combination of pyrimethamine …