Antileishmanial activities of three chalcone derivatives and their association with plasma membrane rigidity as assessed by EPR spectroscopy
EN Borges, L Alonso, MB Silveira, RB Balbinot… - Journal of Molecular …, 2023 - Elsevier
Novel chalcone-like compounds, LQFM332 (4), LQFM333 (5), and LQFM341 (6), were
synthesized and their activity against Leishmania (L.) amazonensis was evaluated and …
synthesized and their activity against Leishmania (L.) amazonensis was evaluated and …
The in Vitro Biological Activity of the Brazilian Brown Seaweed Dictyota mertensii against Leishmania amazonensis
ASS Aliança, KFL dos Anjos, TNV Reis, TMM Higino… - Molecules, 2014 - mdpi.com
Seaweeds present a wide variety of interesting bioactive molecules. In the present work we
evaluated the biological activity of the dichloromethane/methanol (2: 1) extract (DME) from …
evaluated the biological activity of the dichloromethane/methanol (2: 1) extract (DME) from …
Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in …
GM Do Carmo, MD Baldissera, RA Vaucher… - Experimental …, 2015 - Elsevier
This study aimed to verify the effect of the treatment with A. satureioides essential oil (free
and nanoencapsulated forms) and diminazene aceturate on hematological and biochemical …
and nanoencapsulated forms) and diminazene aceturate on hematological and biochemical …
Analysis of the Interactions of Amphotericin B with the Leishmania Plasma Membrane Using EPR Spectroscopy
L Alonso, SA Mendanha, ML Dorta… - The Journal of Physical …, 2020 - ACS Publications
Electron paramagnetic resonance (EPR) spectroscopy of spin labels was used to study the
interactions of amphotericin B (AmB) with the plasma membrane of Leishmania …
interactions of amphotericin B (AmB) with the plasma membrane of Leishmania …
Plasma membrane rigidity effects of 4-hydroxy-2-nonenal in Leishmania, erythrocyte and macrophage
hydroxy-2-nonenal (HNE) is a reactive aldehyde produced by cells under conditions of
oxidative stress, which has been shown to react with proteins and …
oxidative stress, which has been shown to react with proteins and …
[HTML][HTML] 1, 3, 4-Thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones cause death in Trypanosoma cruzi through oxidative stress
SC Martins, D Lazarin-Bidóia, VC Desoti… - Microbes and …, 2016 - Elsevier
This work evaluated the in vitro and in vivo activity of TDZ 2 on Trypanosoma cruzi
amastigotes and determined the possible mechanism of action of this compound on T. cruzi …
amastigotes and determined the possible mechanism of action of this compound on T. cruzi …
[HTML][HTML] C5 induces different cell death pathways in promastigotes of Leishmania amazonensis
EA Mendes, VC Desoti, S de Oliveira Silva… - Chemico-Biological …, 2016 - Elsevier
Leishmaniasis is a neglected infection that is caused by Leishmania protozoa, affecting
millions of people worldwide, mainly in tropical and subtropical regions. This disease has …
millions of people worldwide, mainly in tropical and subtropical regions. This disease has …
Synthesis, antileishmanial activity and spin labeling EPR studies of novel β-carboline-oxazoline and β-carboline-dihydrooxazine derivatives
P Baréa, JC Paula, L Alonso, AR Oliveira… - Journal of the Brazilian …, 2020 - SciELO Brasil
A series of novel 1-(substituted-phenyl)-3-(4, 5-dihydro-1, 3-oxazol-2-yl)-9 H-β-carboline (8a-
8i) and 1-(substituted-phenyl)-3-(5, 6-dihydro-4 H-1, 3-oxazin-2-yl)-9 H-β-carboline (9a-9h) …
8i) and 1-(substituted-phenyl)-3-(5, 6-dihydro-4 H-1, 3-oxazin-2-yl)-9 H-β-carboline (9a-9h) …
Biogenic trypanocidal sesquiterpenes: lead compounds to design future trypanocidal drugs-a mini review
Human trypanosomiasis is a parasitic disease among poor people in Africa and Latin
America. Therapy against African and American trypanosomiasis is based on a few drugs …
America. Therapy against African and American trypanosomiasis is based on a few drugs …
The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process
V Cristina Desoti, D Lazarin-Bidoia, F Martins Ribeiro… - PLoS …, 2015 - journals.plos.org
Chagas' disease is an infection that is caused by the protozoan Trypanosoma cruzi, affecting
millions of people worldwide. Because of severe side effects and variable efficacy, the …
millions of people worldwide. Because of severe side effects and variable efficacy, the …