In the past years, the drug discovery programs of the scientific community have shifted from
screening of purely synthetic drugs enabled by combinatory chemistry to natural …

The marine environment is an important source of structurally-diverse and biologically-active
secondary metabolites. During the last two decades, thousands of compounds were …

Abstract Purpose: The DEAD-box RNA helicase eIF4A1 carries out the key enzymatic step of
capdependent translation initiation and is a well-established target for cancer therapy, but …

A doença de Chagas constitui um sério problema de saúde pública em toda a América
Latina e particularmente no Brasil. Os tratamentos disponíveis para esta doença se limitam …

Despite decades of research identifying molecular drivers of cancer, targeted therapies fail
to provide long-term survival benefits for cancer patients much of the time, primarily due to …

Leishmaniasis is a disease that affects millions of people worldwide. The drugs that are
available for the treatment of this infection exhibit high toxicity and various side effects …

Activation of pathways resulting in an overexpression of oncoproteins, reliant on cap-
dependent translation, or mutations of key proteins in a pathway can be advantageous to …