Synchronous bursting (SB) is ubiquitous in neuronal networks and independent of network
structure. Although it is known to be driven by glutamatergic neurotransmissions, its …

Background Mutations in MECP2 predominantly cause Rett syndrome and can be modeled
in vitro using human stem cell–derived neurons. Patients with Rett syndrome have signs of …

Rett syndrome (RTT) patients show abnormal developmental trajectories including loss of
language and repetitive hand movements but also have signs of cortical hyperexcitability …

Variants in the gene encoding the postsynaptic scaffolding protein SHANK2 are associated
with several neurodevelopmental disorders, including autism spectrum disorder. Here, we …

Fragmented network bursts (NBs) are observed as a phenotypic driver in many patient-
derived neuronal networks on multi-electrode arrays (MEAs), but the pathophysiological …

Autism spectrum disorder (ASD) is etiologically complex and is associated with a multitude
of genetic mutations, many of which disrupt genes that encode proteins important for proper …

In modern neuroscience, memory has been postulated to stored in neural circuits as
sequential spike train and Reverberation is one of the specific example. Former research …

Spontaneous focal synchronization of collective spiking followed by induced traveling waves
can occur in the cortical sheet and in cultured planar neuronal networks. In the first case, it is …