Toxicity is a leading cause of attrition at all stages of the drug development process. The
majority of safety-related attrition occurs preclinically, suggesting that approaches to …

Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and
anti-oxidant effects. These are thought to be responsible for the potential effects of statins on …

Quinones and quinone imines are highly reactive metabolites (RMs) able to induce
dangerous effects in vivo. They are responsible for all kinds of toxicity, for example …

Consumption of soy has been demonstrated to reduce circulating cholesterol levels, most
notably reducing low-density lipoprotein (LDL) cholesterol levels in hypercholesterolemic …

The safety and tolerability of the available statins support their use as the first-line treatment
of patients at high risk for coronary heart disease, since the clinical benefits greatly outweigh …

1. To gain a better understanding of the metabolic properties between the open acid and
lactone form of HMG-CoA reductase inhibitors (statins), the paper focused primarily on …

The prevention of cardiovascular disease is critically dependent on lipid-lowering therapy,
including 3-hydroxymethyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors …

Controlled clinical studies and clinical experience over many years have proven that
virtually all patients benefit from lipid-lowering therapy with statins, even those with normal …

Purpose: The frequency, onset, mechanisms, and causes of dyslipidemia after renal
transplantation are reviewed in the context of the adverse impact of lipid alterations, recent …

OBJECTIVE: To report a case of severe myopathy associated with concomitant simvastatin
and amiodarone therapy. CASE SUMMARY: A 63-year-old white man with underlying …