Proksee: in-depth characterization and visualization of bacterial genomes

JR Grant, E Enns, E Marinier, A Mandal… - Nucleic acids …, 2023 - academic.oup.com
Abstract Proksee (https://proksee. ca) provides users with a powerful, easy-to-use, and
feature-rich system for assembling, annotating, analysing, and visualizing bacterial …

Emerging tools and best practices for studying gut microbial community metabolism

C Noecker, PJ Turnbaugh - Nature Metabolism, 2024 - nature.com
The human gut microbiome vastly extends the set of metabolic reactions catalysed by our
own cells, with far-reaching consequences for host health and disease. However, our …

[HTML][HTML] Host genetic regulation of human gut microbial structural variation

DV Zhernakova, D Wang, L Liu, S Andreu-Sánchez… - Nature, 2024 - nature.com
Although the impact of host genetics on gut microbial diversity and the abundance of specific
taxa is well established,,,,–, little is known about how host genetics regulates the genetic …

Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock

G Yebra, JD Harling-Lee, S Lycett… - Proceedings of the …, 2022 - National Acad Sciences
Most new pathogens of humans and animals arise via switching events from distinct host
species. However, our understanding of the evolutionary and ecological drivers of …

Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight

BT Tierney, JK Kim, EG Overbey, KA Ryon, J Foox… - Nature …, 2024 - nature.com
Maintenance of astronaut health during spaceflight will require monitoring and potentially
modulating their microbiomes. However, documenting microbial shifts during spaceflight has …

Challenges in prokaryote pangenomics

G Tonkin-Hill, J Corander, J Parkhill - Microbial Genomics, 2023 - microbiologyresearch.org
Horizontal gene transfer (HGT) and the resulting patterns of gene gain and loss are a
fundamental part of bacterial evolution. Investigating these patterns can help us to …

Syntrophic entanglements for propionate and acetate oxidation under thermophilic and high-ammonia conditions

A Singh, A Schnürer, J Dolfing… - The ISME …, 2023 - academic.oup.com
Propionate is a key intermediate in anaerobic digestion processes and often accumulates in
association with perturbations, such as elevated levels of ammonia. Under such conditions …

H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity

SP Methot, J Padeken, G Brancati, P Zeller… - Nature cell …, 2021 - nature.com
The developmental role of histone H3K9 methylation (H3K9me), which typifies
heterochromatin, remains unclear. In Caenorhabditis elegans, loss of H3K9me leads to a …

Plassembler: an automated bacterial plasmid assembly tool

G Bouras, AE Sheppard, V Mallawaarachchi… - …, 2023 - academic.oup.com
With recent advances in sequencing technologies, it is now possible to obtain near-perfect
complete bacterial chromosome assemblies cheaply and efficiently by combining a long …

Enhanced bacterium–phage symbiosis in attached microbial aggregates on a membrane surface facing elevated hydraulic stress

Y Tan, P Yu, D Huang, MM Yuan, Z Yu… - Environmental …, 2023 - ACS Publications
Phages are increasingly recognized for their importance in microbial aggregates, including
their influence on microbial ecosystem services and biotechnology applications. However …