[HTML][HTML] Pan-cancer proteogenomics connects oncogenic drivers to functional states
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan …
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan …
[HTML][HTML] Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
DNA methylation plays a critical role in establishing and maintaining cellular identity.
However, it is frequently dysregulated during tumor development and is closely intertwined …
However, it is frequently dysregulated during tumor development and is closely intertwined …
[HTML][HTML] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
[HTML][HTML] Integration of pan-omics technologies and three-dimensional in vitro tumor models: an approach toward drug discovery and precision medicine
A Jose, P Kulkarni, J Thilakan, M Munisamy… - Molecular Cancer, 2024 - Springer
Despite advancements in treatment protocols, cancer is one of the leading cause of deaths
worldwide. Therefore, there is a need to identify newer and personalized therapeutic targets …
worldwide. Therefore, there is a need to identify newer and personalized therapeutic targets …
A proteogenomics data-driven knowledge base of human cancer
By combining mass-spectrometry-based proteomics and phosphoproteomics with genomics,
epi-genomics, and transcriptomics, proteogenomics provides comprehensive molecular …
epi-genomics, and transcriptomics, proteogenomics provides comprehensive molecular …
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability
M Takahashi, HB Chong, S Zhang, TY Yang… - Cell, 2024 - cell.com
Cysteine-focused chemical proteomic platforms have accelerated the clinical development
of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic …
of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic …
Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide
The connection and causality between cancer and neurodevelopmental disorders have
been puzzling. How can the same cellular pathways, proteins, and mutations lead to …
been puzzling. How can the same cellular pathways, proteins, and mutations lead to …
[HTML][HTML] TMO-Net: an explainable pretrained multi-omics model for multi-task learning in oncology
F Wang, Z Zhuang, F Gao, R He… - Genome …, 2024 - genomebiology.biomedcentral.com
Cancer is a complex disease composing systemic alterations in multiple scales. In this study,
we develop the Tumor Multi-Omics pre-trained Network (TMO-Net) that integrates multi …
we develop the Tumor Multi-Omics pre-trained Network (TMO-Net) that integrates multi …
ClinicalOmicsDB: exploring molecular associations of oncology drug responses in clinical trials
Matching patients to optimal treatment is challenging, in part due to the limited availability of
real-world clinical datasets for predictive biomarker identification. The growing integration of …
real-world clinical datasets for predictive biomarker identification. The growing integration of …
[HTML][HTML] Directional integration and pathway enrichment analysis for multi-omics data
M Slobodyanyuk, AT Bahcheli, ZP Klein… - Nature …, 2024 - nature.com
Omics techniques generate comprehensive profiles of biomolecules in cells and tissues.
However, a holistic understanding of underlying systems requires joint analyses of multiple …
However, a holistic understanding of underlying systems requires joint analyses of multiple …