The tumor suppressor p53 and its oncogenic sibling p63 (ΔNp63) direct opposing fates in
tumor development. These paralog proteins are transcription factors that elicit their tumor …

Transcription factor p63 is a key regulator of epidermal keratinocyte proliferation and
differentiation. Mutations in the p63 DNA-binding domain are associated with ectrodactyly …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide, and several molecular pathways that underlie the molecular tumorigenesis of …

During physiological aerobic metabolism, the epidermis undergoes significant oxidative
stress as a result of the production of reactive oxygen species (ROS). To maintain a …

Effective targeted therapeutics for squamous cell carcinoma (SCC) are lacking. Here, we
uncover Mcl-1 as a dominant and tissue-specific survival factor in SCC, providing a roadmap …

The high percentage of p53 missense mutations found in cancer has been attributed to
mutant acquired oncogenic gain of functions. Different aspects of these tumour-promoting …

Abstract B-cell lymphoma-2 (Bcl-2) proteins family is an essential checkpoint in apoptosis.
Extensive evidences suggested that overexpression of anti-apoptotic Bcl-2 proteins can be …

The transcriptional repressor ΔNp63α is a potent oncogene widely overexpressed in
squamous cell carcinomas (SCCs) of diverse tissue origins, where it promotes malignant …

The histone modifying enzymes (HME) represent particularly promising targets for the
development of alternatives to praziquantel, the only currently available drug to combat …

The histone deacetylases HDAC1 and HDAC2 remove acetyl moieties from lysine residues
of histones and other proteins and are important regulators of gene expression. By deleting …