Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer

M Ma, C Li, Y Zhang, M Weng, M Zhang, Y Qin… - Molecular cancer, 2014 - Springer
Background Protein coding genes account for only about 2% of the human genome,
whereas the vast majority of transcripts are non-coding RNAs including long non-coding …

A functional lncRNA HOTAIR genetic variant contributes to gastric cancer susceptibility

W Pan, L Liu, J Wei, Y Ge, J Zhang… - Molecular …, 2016 - Wiley Online Library
Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an
oncogene in gastric cancer development. HOTAIR could induce genome‐wide retargeting of …

Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells

C Lin, Y Wang, S Zhang, L Yu, C Guo, H Xu - Oncogene, 2017 - nature.com
The long non-coding RNA, HOTTIP, has an important role in tumorigenesis. It is known that
HOTTIP regulates HOX gene family; however, its regulatory mechanism in esophageal …

The identification of an ESCC susceptibility SNP rs920778 that regulates the expression of lncRNA HOTAIR via a novel intronic enhancer

X Zhang, L Zhou, G Fu, F Sun, J Shi, J Wei, C Lu… - …, 2014 - academic.oup.com
Abstract Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR), which
could induce genome-wide retargeting of polycomb-repressive complex 2, trimethylates …

Long non-coding RNA HOTAIR functions as miRNA sponge to promote the epithelial to mesenchymal transition in esophageal cancer

F Xu, J Zhang - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Background Accumulating evidence indicates dysregulated expression of the long non-
coding RNA HOTAIR (lncRNA-HOTAIR) may play a significant role in tumor progression …

Elevated expression of CCAT2 is associated with poor prognosis in esophageal squamous cell carcinoma

X Zhang, Y Xu, C He, X Guo, J Zhang… - Journal of surgical …, 2015 - Wiley Online Library
Background and Objectives CCAT2, a novel long non‐coding RNAs (lncRNAs), is found to
promote the metastasis and invasion of colon, lung, and breast cancers. This study aimed to …

Long noncoding RNA plays a key role in metastasis and prognosis of hepatocellular carcinoma

G Li, H Zhang, X Wan, X Yang, C Zhu… - BioMed research …, 2014 - Wiley Online Library
Long noncoding RNAs (lncRNAs) have been attracting immense research interests.
However, only a handful of lncRNAs had been thoroughly characterized. They were …

The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells

J Heubach, J Monsior, R Deenen, G Niegisch… - Molecular cancer, 2015 - Springer
Background Urothelial carcinoma (UC) is the fifth most common cancer in the developed
world. Delineation of differentiation subtypes in UC highlighted the importance of aberrant …

LncRNA MEG3 promotes cisplatin sensitivity of cervical cancer cells by regulating the miR-21/PTEN axis

Y Du, G Geng, C Zhao, T Gao, B Wei - BMC cancer, 2022 - Springer
Background Cervical cancer (CC) is a common gynecological malignancy worldwide. Some
patients perform serious resistance after chemotherapy, and long-stranded non-coding RNA …

HOTAIR: A key regulator of the Wnt/β-catenin signaling cascade in cancer progression and treatment

MA Hakami, A Hazazi, O Abdulaziz… - … -Research and Practice, 2023 - Elsevier
The long non-coding RNA (lncRNA) HOTAIR occupies a central position in the complex
domain of cancer biology, particularly concerning its intricate interplay with the Wnt/β …