In the genesis and progression of cardiovascular diseases involving both innate and
adaptive immune responses, inflammation plays a pivotal and dual role. Studies in …

This report describes major pathomechanisms of disease in which the dysregulation of host
inflammatory processes is a major factor, with cardiovascular disease (CVD) as a primary …

Familial dilated cardiomyopathy (DCM) is among the leading indications for heart
transplantation. DCM alters the transcriptomic profile. The alteration or activation/silencing of …

Much effort has been made to uncover the cellular heterogeneities of human hearts by
single-nucleus RNA sequencing. However, the cardiac transcriptional regulation networks …

Ventricular remodeling refers to the structural and functional changes of the heart under
various stimuli or disease influences and may also be accompanied by myocardial fibrosis …

Cardiomyopathies (CMPs) are a group of myocardial disorders that are characterized by
structural and functional abnormalities of the heart muscle. These abnormalities occur in the …

Background Variants in cardiomyopathy genes have been identified in patients with cancer
therapy-related cardiac dysfunction (CTRCD), suggesting a genetic predisposition for the …

Investigating the causes of Sudden cardiac death (SCD) is always difficult; in fact, genetic
cardiac conditions associated with SCD could be “silent” even during autopsy investigation …

Background Dilated cardiomyopathy (DCM) is a severe heterogeneous cardiomyopathy
characterized by cardiac enlargement and declining heart function, often leading to …

Dilated cardiomyopathy (DCM) is one of the most common primary myocardial diseases.
However, to this day, it remains an enigmatic cardiovascular disease (CVD) characterized …