The pediatric common variable immunodeficiency—from genetics to therapy: a review

A Szczawinska-Poplonyk, E Schwartzmann… - European Journal of …, 2022 - Springer
Common variable immunodeficiency (CVID) is the most prevalent antibody deficiency,
characterized by remarkable genetic, immunological, and clinical heterogeneity. The …

Lymphocytes subsets in correlation with clinical profile in CVID patients without monogenic defects

F Tofighi Zavareh, A Mirshafiey, R Yazdani… - Expert Review of …, 2021 - Taylor & Francis
Objectives: Common variable immunodeficiency (CVID) patients experience clinical
manifestations rather than recurrent respiratory infections including autoimmunity …

HCoV-and SARS-CoV-2 cross-reactive T cells in CVID patients

S Steiner, F Sotzny, S Bauer, IK Na… - Frontiers in …, 2020 - frontiersin.org
The inability of patients with CVID to mount specific antibody responses to pathogens has
raised concerns on the risk and severity of SARS-CoV-2 infection, but there might be a role …

Evaluation of clinical and immunological alterations associated with ICF syndrome

S Bilgic Eltan, E Nain, MC Catak, E Ezen… - Journal of Clinical …, 2024 - Springer
Purpose Immunodeficiency with centromeric instability and facial anomalies (ICF) syndrome
is a rare autosomal recessive combined immunodeficiency. The detailed immune responses …

Immunophenotypic and functional analysis of lymphocyte subsets in common variable immunodeficiency patients without monogenic defects

F Tofighi Zavareh, A Mirshafiey… - Scandinavian …, 2022 - Wiley Online Library
Common variable immunodeficiency (CVID) is accompanied by various lymphocyte
abnormalities believed to be mostly responsible for disease features in patients with no …

Clinical and laboratory factors affecting the prognosis of severe combined immunodeficiency

E Ozturk, MC Catak, A Kiykim, D Baser… - Journal of Clinical …, 2022 - Springer
Purpose Severe combined immunodeficiency (SCID) is one of the most severe forms of
inborn errors of immunity characterized by absence or loss of function in T cells. The long …

Reference values for T and B lymphocyte subpopulations in Turkish children and adults

Ö Besci, D Başer, İ Öğülür… - Turkish journal of …, 2021 - journals.tubitak.gov.tr
Background/aim: Established reference values are critical for the interpretation of
immunologic assessments. In particular, the proportion and absolute counts of T-and B-cell …

Immune dysregulation in pediatric common variable immunodeficiency: implications for the diagnostic approach

A Szczawińska-Popłonyk, K Ta̧polska-Jóźwiak… - Frontiers in …, 2022 - frontiersin.org
Infections and infectious complications are hallmarks of common variable immunodeficiency
(CVID) and the leading cause of morbidity and mortality in affected patients at any age …

Soluble interleukin-2 receptor is a promising serum biomarker for granulomatous disease in common variable immune deficiency

AC van Stigt, VASH Dalm, NMA Nagtzaam… - Journal of Clinical …, 2021 - Springer
To the editor: Common variable immune deficiency (CVID) is a primary antibody deficiency
characterized by a marked decrease of immunoglobulin (Ig) G in combination with low IgA …

Altered immune response in organic acidemia

I Altun, A Kiykim, T Zubarioglu… - Pediatrics …, 2022 - Wiley Online Library
Background Most patients with organic acidemia suffer from recurrent infections. Although
neutropenia has been reported in multiple studies, other components of the immune system …