Background Osteoporosis is a widespread and serious metabolic bone disease. At present,
revealing the molecular mechanisms of osteoporosis and developing effective prevention …

Obstetric and newborn outcomes of assisted reproductive technology (ART) pregnancies
are associated with significative prevalence of maternal and neonatal adverse health …

Maternal effect genes (MEGs) encode factors (eg, RNA) that are present in the oocyte and
required for early embryonic development. Hence, while these genes and gene products are …

Adrenal cortical carcinoma (ACC) is a rare and aggressive malignancy that poses
challenging issues regarding the diagnostic workup. Indeed, no presurgical technique or …

Abstract Background Imprinting disorders (ImpDis) comprise diseases which are caused by
aberrant regulation of monoallelically and parent-of-origin-dependent expressed genes. A …

Beckwith–Wiedemann syndrome (BWS) is a congenital overgrowth disorder caused by
various (epi) genetic alterations affecting the expression of genes on chromosome 11p15 …

Due to associated maxillofacial growth anomalies and the impairment of oral functions,
macroglossia may negatively impact the oral health-related quality of life (OHRQoL) of …

Detection of structural variants (SVs) is currently biased toward those that alter copy number.
The relative contribution of inversions toward genetic disease is unclear. In this study, we …

Objectives The role of tongue reduction surgery (TRS) in preventing excessive mandibular
growth and anterior open bite in children with Beckwith–Wiedemann Spectrum (BWSp) is …

Background Prepubertal children with obesity frequently have enhanced growth,
accelerated skeletal maturation, and changes in the growth hormone–insulin-like growth …