Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation …

Mitochondria are essential organelles performing important cellular functions ranging from
bioenergetics and metabolism to apoptotic signaling and immune responses. They are …

Mitochondrial stress triggers a response in the cell's mitochondria and nucleus, but how
these stress responses are coordinated in vivo is poorly understood. Here, we characterize …

Mitochondrial dysfunction is becoming one of the main pathology factors involved in the
etiology of neurological disorders. Recently, mutations of the coiled-coil-helix-coiled-coil …

Parkinson's disease (PD) and frontotemporal dementia/amyotrophic lateral sclerosis
(FTD/ALS) are insidious and incurable neurodegenerative diseases that represent a …

Mitochondria play a key role in cellular signalling, metabolism and energetics. Proper
architecture and remodelling of the inner mitochondrial membrane are essential for efficient …

The 'mitochondrial contact site and cristae organising system'(MICOS) is an essential protein
complex that promotes the formation, maintenance and stability of mitochondrial cristae. As …

Mutations in CHCHD10, coding for a mitochondrial intermembrane space protein, are a rare
cause of autosomal dominant amyotrophic lateral sclerosis. Mutation-specific toxic gain of …

Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

Rare mutations in the mitochondrial protein coiled-coil-helix-coiled-coil-helix domain
containing 2 (CHCHD2) are associated with Parkinson's disease (PD) and other Lewy body …