Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

One in three people will be diagnosed with cancer during their lifetime. The community of
cancer patients is growing, and several common cancers are becoming increasingly …

There are a number of potential implications for the field of Alzheimer's disease (AD)
stemming from the global spread of SARS-CoV-2. Neuroinflammation is known to be a …

Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

Substance use disorders (SUDs) are characterized by a compulsion to seek and consume
one or more substances of abuse, with a perceived loss of control and a negative emotional …

Mouse models of Alzheimer's disease (AD) are valuable but do not fully recapitulate human
AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss …

Abstract Anatoxin-a (ATX-a) is a neurotoxic alkaloid, produced by several freshwater
planktonic and benthic cyanobacteria (CB). Such CB have posed human and animal health …

Nicotine, the primary psychoactive agent in tobacco leaves, has led to the widespread use of
tobacco, with over one billion smokers globally. This article provides a historical overview of …

The development of the next generation therapy for Alzheimer's disease (AD) presents a
huge challenge given the number of promising treatment candidates that failed in trials …