Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …

The mechanistic target of rapamycin (mTOR) network is an evolutionary conserved signaling
hub that senses and integrates environmental and intracellular nutrient and growth factor …

Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Simple Summary PI3K signaling pathway plays an essential role in many cellular processes
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Lysosomes are highly dynamic organelles that can move rapidly throughout the cell. They
distribute in a rather immobile pool located around the microtubule‐organizing center in a …

Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …

Lysosomes are in the center of the cellular control of catabolic and anabolic processes.
These membrane-surrounded acidic organelles contain around 70 hydrolases, 200 …