A receptor heteromer mediates the male perception of female attractants in plants

T Wang, L Liang, Y Xue, PF Jia, W Chen, MX Zhang… - Nature, 2016 - nature.com
Sexual reproduction requires recognition between the male and female gametes. In
flowering plants, the immobile sperms are delivered to the ovule-enclosed female …

Polysulfurating reagent design for unsymmetrical polysulfide construction

X Xiao, J Xue, X Jiang - Nature communications, 2018 - nature.com
From life science to material science, to pharmaceutical industry, and to food chemistry,
polysulfides are vital structural scaffolds. However, there are limited synthetic methods for …

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

Z Su, JG Burchfield, P Yang, SJ Humphrey… - Nature …, 2019 - nature.com
Protein oxidation sits at the intersection of multiple signalling pathways, yet the magnitude
and extent of crosstalk between oxidation and other post-translational modifications remains …

Unsymmetrical polysulfidation via designed bilateral disulfurating reagents

J Xue, X Jiang - Nature Communications, 2020 - nature.com
Sulfur-sulfur motifs widely occur in vital function and drug design, which yearns for
polysulfide construction in an efficient manner. However, it is a great challenge to install …

Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope

Y Wu, Y Zhu, F Gao, Y Jiao… - Proceedings of the …, 2017 - National Acad Sciences
Severe fever with thrombocytopenia syndrome virus (SFTSV) and Rift Valley fever virus
(RVFV) are two arthropod-borne phleboviruses in the Bunyaviridae family, which cause …

Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT

W Han, M Jin, C Liu, Q Zhao, S Wang, Y Wang… - Science …, 2023 - science.org
The cytoskeletal proteins tubulin and actin are the obligate substrates of TCP-1 ring
complex/Chaperonin containing TCP-1 (TRiC/CCT), and their folding involves co …

Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD

S Su, J Wang, T Deng, X Yuan, J He, N Liu, X Li… - Nature, 2022 - nature.com
Small interfering RNAs (siRNAs) are the key components for RNA interference (RNAi), a
conserved RNA-silencing mechanism in many eukaryotes,. In Drosophila, an RNase III …

N‐(Morpholine‐4‐dithio)phthalimide: A Shelf‐Stable, Bilateral Platform Molecule Enabling Access to Diverse Unsymmetrical Disulfides**

H Asanuma, K Kanemoto, T Watanabe… - Angewandte …, 2023 - Wiley Online Library
Synthetic methods for unsymmetrical disulfides are greatly needed owing to their
applications in drug discovery, linker chemistry, and materials sciences. In this study, a new …

Detecting post-translational modification signatures as potential biomarkers in clinical mass spectrometry

R Mnatsakanyan, G Shema, M Basik… - Expert Review of …, 2018 - Taylor & Francis
Introduction: Numerous diseases are caused by changes in post-translational modifications
(PTMs). Therefore, the number of clinical proteomics studies that include the analysis of …

Architecture of the baculovirus nucleocapsid revealed by cryo-EM

X Jia, Y Gao, Y Huang, L Sun, S Li, H Li… - Nature …, 2023 - nature.com
Baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) has been
widely used as a bioinsecticide and a protein expression vector. Despite their importance …