[HTML][HTML] Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ

J Chen, Y Wang, C Xu, K Chen, Q Zhao, S Wang… - Nature …, 2021 - nature.com
The proteasome activator PA28αβ affects MHC class I antigen presentation by associating
with immunoproteasome core particles (iCPs). However, due to the lack of a mammalian …

IgE recognition and structural analysis of disulfide bond rearrangement and chemical modifications in allergen aggregations in roasted peanuts

Y Zhang, M Song, J Xu, X Li, A Yang… - Journal of Agricultural …, 2023 - ACS Publications
Given that roasting changes the structure and allergenicity of peanut allergens, the structural
information of peanut allergens must be expounded to explain the alteration in their …

Nickel-Catalyzed Deoxygenative Disulfuration of Alcohols to Access Unsymmetrical Disulfides

X Chen, W Shao, GJ Deng - ACS Catalysis, 2024 - ACS Publications
Given the abundance of alcohol feedstocks and the significance of disulfides, we herein
report a nickel-catalyzed direct deoxygenative disulfuration of alcohols with trisulfide …

[HTML][HTML] Nanosecond photochemically promoted click chemistry for enhanced neuropeptide visualization and rapid protein labeling

G Li, F Ma, Q Cao, Z Zheng, K DeLaney, R Liu… - Nature …, 2019 - nature.com
Comprehensive protein identification and concomitant structural probing of proteins are of
great biological significance. However, this is challenging to accomplish simultaneously in …

Phycobilisomes Harbor FNRL in Cyanobacteria

H Liu, DA Weisz, MM Zhang, M Cheng, B Zhang… - MBio, 2019 - Am Soc Microbiol
Cyanobacterial phycobilisomes (PBSs) are photosynthetic antenna complexes that harvest
light energy and supply it to two reaction centers (RCs) where photochemistry starts. PBSs …

EThcD Benefits for the Sequencing Inside Intramolecular Disulfide Cycles of Amphibian Intact Peptides

ID Vasileva, TY Samgina, Z Meng… - Journal of the …, 2023 - ACS Publications
Disulfide bonds formed by a pair of cysteine residues in the peptides' backbone represent a
certain problem for their sequencing by means of mass spectrometry. As a rule, in …

Complete mapping of complex disulfide patterns with closely-spaced cysteines by in-source reduction and data-dependent mass spectrometry

CN Cramer, CD Kelstrup, JV Olsen… - Analytical …, 2017 - ACS Publications
Mapping of disulfide bonds is an essential part of protein characterization to ensure correct
cysteine pairings. For this, mass spectrometry (MS) is the most widely used technique due to …

Electrochemical reverse engineering: a systems-level tool to probe the redox-based molecular communication of biology

J Li, Y Liu, E Kim, JC March, WE Bentley… - Free Radical Biology and …, 2017 - Elsevier
The intestine is the site of digestion and forms a critical interface between the host and the
outside world. This interface is composed of host epithelium and a complex microbiota …

Top-down characterization of proteins with intact disulfide bonds using activated-ion electron transfer dissociation

MJP Rush, NM Riley, MS Westphall… - Analytical chemistry, 2018 - ACS Publications
Here we report the fragmentation of disulfide linked intact proteins using activated-ion
electron transfer dissociation (AI-ETD) for top-down protein characterization. This …

A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement

AP Rebelo, A Cortese, A Abraham, Y Eshed-Eisenbach… - Brain, 2021 - academic.oup.com
The CADM family of proteins consists of four neuronal specific adhesion molecules
(CADM1, CADM2, CADM3 and CADM4) that mediate the direct contact and interaction …