Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

Obesity plays relevant pathophysiological role in the development of health problems,
arising as result of complex interaction of genetic, nutritional, and metabolic factors. Due to …

The prevalence and severity of obesity have increased in recent years, likely the result of
complex interactions between genes, dietary intake, physical activity, and the environment …

The increasing occurrence of obesity has become a significant public health concern.
Individuals with obesity have higher prevalence of heart disease, stroke, osteoarthritis …

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with
body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of …

The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally …