Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease

M Kumar, N Bansal - Molecular neurobiology, 2022 - Springer
Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

Nicotinic ACh receptors as therapeutic targets in CNS disorders

KT Dineley, AA Pandya, JL Yakel - Trends in pharmacological sciences, 2015 - cell.com
The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

Neural stem cell differentiation into mature neurons: mechanisms of regulation and biotechnological applications

MS Vieira, AK Santos, R Vasconcellos… - Biotechnology …, 2018 - Elsevier
The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …

Regulation of neurogenesis by calcium signaling

AB Toth, AK Shum, M Prakriya - Cell calcium, 2016 - Elsevier
Abstract Calcium (Ca 2+) signaling has essential roles in the development of the nervous
system from neural induction to the proliferation, migration, and differentiation of neural cells …

Human adult stem cells from diverse origins: an overview from multiparametric immunophenotyping to clinical applications

BR Sousa, RC Parreira, EA Fonseca… - Cytometry Part …, 2014 - Wiley Online Library
Stem cells are known for their capacity to self‐renew and differentiate into at least one
specialized cell type. Mesenchymal stem cells (MSCs) were isolated initially from bone …

The association between prenatal exposure to phthalates and cognition and neurobehavior of children-evidence from birth cohorts

Q Zhang, XZ Chen, X Huang, M Wang, J Wu - Neurotoxicology, 2019 - Elsevier
Background Phthalate have been detected widely in the environment; while several studies
have indicated that prenatal phthalate exposure has adverse effects on neurodevelopment …

Developmental neurotoxicity of ortho-phthalate diesters: review of human and experimental evidence

A Miodovnik, A Edwards, DC Bellinger, R Hauser - Neurotoxicology, 2014 - Elsevier
Ortho-phthalate diesters, or phthalates, are widely used synthetic chemicals found primarily
in consumer products and polyvinyl chloride plastics. Experimental evidence suggests that …

Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells

A Somasundaram, AK Shum, HJ McBride… - Journal of …, 2014 - Soc Neuroscience
Calcium signals regulate many critical processes during vertebrate brain development
including neurogenesis, neurotransmitter specification, and axonal outgrowth. However, the …

The role of G protein-coupled receptors (GPCRs) and calcium signaling in schizophrenia. Focus on GPCRs activated by neurotransmitters and chemokines

T Boczek, J Mackiewicz, M Sobolczyk, J Wawrzyniak… - Cells, 2021 - mdpi.com
Schizophrenia is a common debilitating disease characterized by continuous or relapsing
episodes of psychosis. Although the molecular mechanisms underlying this psychiatric …

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

FMP Tonelli, AK Santos, KN Gomes… - International journal …, 2012 - Taylor & Francis
In recent years, significant progress has been made in organ transplantation, surgical
reconstruction, and the use of artificial prostheses to treat the loss or failure of an organ or …