A study of structure-based modulation of known ligands of hTopoIIα, an important enzyme
involved in DNA processes, coupled with synthesis and in vitro assays led to the …

A combination of biochemical, biophysical and biological techniques was used to study calf
thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12–17 and urea …

We reported that suramin is an effective chemosensitizer at noncytotoxic concentrations (<
50 μM); this effect was observed in multiple types of human xenograft tumors in vitro and in …

Purpose In preclinical models, non-cytotoxic suramin (concentrations< 50 μM) potentiates
the activity of multiple chemotherapeutic agents. The present study evaluated the safety and …

Metastatic disease accounts for most deaths due to breast cancer and thus identification of
novel ways to prevent this complication remains a key goal. A frequently employed …

Objectives We investigated the effect of suramin on tumor growth and spread in an
immunocompetent, orthotopic rat model of pancreatic cancer and analyzed the tumor …

Nanomedicine, which has the advantage of enhancing drug efficacy while attenuating side
effects, has been extensively explored in repurposing drugs, especially for cancer therapy …

Objective: Suramin is a polysulphonated napthylurea antiprotozoal and anthelminitic drug,
which also presents inhibitory activity against a broad range of enzymes. Here we evaluate …

Laboratory scientists in cancer research typically focus on unraveling the molecular basis of
carcinogenesis, identifying novel cellular and molecular targets for interventions, and …

Translational research bridges preclinical and clinical research and shortens distance
between these two areas in biomedical research. In preclinical study, our laboratory has …