Diabetic peripheral neuropathy (DPN) occurs in up to half of individuals with type 1 or type 2
diabetes. DPN results from the distal-to-proximal loss of peripheral nerve function, leading to …

Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

The fecal microbiome of 55 obese children and adolescents (BMI-SDS 3.2±0.7) and of 25
normal-weight subjects, matched both for age and sex (BMI-SDS− 0.3±1.1) was analysed …

Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not
well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting …

Highlights•The mechanism of HGWD intervention DPN was studied for the first time by
combining metabolomics and microbiomics.•HGWD can ameliorate the phenotype of …

As the prevalence of prediabetes and type 2 diabetes (T2D) continues to increase
worldwide, accompanying complications are also on the rise. The most prevalent …

Purpose Type 2 diabetes mellitus (T2DM) with distal symmetric polyneuropathy (DSPN) is a
disease involving the nervous system caused by metabolic disorder, while the metabolic …

Diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN) are common
complications of type 1 (T1D) and type 2 (T2D) diabetes. However, the mechanisms …

Introduction As the most common chronic complication of diabetes mellitus (DM), diabetic
peripheral neuropathy (DPN) seriously affects the quality of life of DM patients. So, it is of …