[HTML][HTML] Friend or foe? An unrecognized role of uric acid in cancer development and the potential anticancer effects of uric acid-lowering drugs

S Mi, L Gong, Z Sui - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
In recent years, metabolic syndrome (Mets) has been a hot topic among medical scientists.
Mets has an intimate relationship with the incidence and development of various cancers. As …

U‐shaped association between serum uric acid level and risk of mortality: a cohort study

SK Cho, Y Chang, I Kim, S Ryu - Arthritis & rheumatology, 2018 - Wiley Online Library
Objective In addition to the controversy regarding the association of hyperuricemia with
cardiovascular disease (CVD) mortality, few studies have examined the impact of a low uric …

Adenosine, Schizophrenia and Cancer: Does the Purinergic System Offer a Pathway to Treatment?

AR Hamoud, K Bach, O Kakrecha, N Henkel… - International Journal of …, 2022 - mdpi.com
For over a century, a complex relationship between schizophrenia diagnosis and
development of many cancers has been observed. Findings from epidemiological studies …

Hyperuricemia and gout are associated with cancer incidence and mortality: a meta‐analysis based on cohort studies

Y Xie, P Xu, K Liu, S Lin, M Wang, T Tian… - Journal of cellular …, 2019 - Wiley Online Library
The association between hyperuricemia or gout and cancer risk has been investigated in
various published studies, but their results are conflicting. We conducted a meta‐analysis to …

High serum uric acid may associate with the increased risk of colorectal cancer in females: a prospective cohort study

N Mi, J Huang, C Huang, Y Lin, Q He… - … journal of cancer, 2022 - Wiley Online Library
Elevated serum uric acid (SUA) levels have been previously reported to play a role in
multiple types of cancers. However, epidemiological studies evaluating SUA levels and …

Correlation of metabolic factors with endometrial atypical hyperplasia and endometrial cancer: development and assessment of a new predictive nomogram

H Zhang, W Kong, C Han, T Liu, J Li… - Cancer Management …, 2021 - Taylor & Francis
Purpose This study aimed to investigate the association of metabolic factors with
endometrial atypical hyperplasia and endometrial cancer, and to develop a nomogram …

Uric acid mediated the association between BMI and postmenopausal breast cancer incidence: a bidirectional mendelian randomization analysis and prospective …

Y Feng, M Fu, X Guan, C Wang, F Yuan, Y Bai… - Frontiers in …, 2022 - frontiersin.org
Background Observational epidemiological studies have reported the associations of high
body mass index (BMI) with elevated serum uric acid (UA) level and increased risk of …

Analysis of the prognostic value of uric acid on the efficacy of immunotherapy in patients with primary liver cancer

H Rao, Q Wang, X Zeng, X Wen, L Huang - Clinical and Translational …, 2024 - Springer
Purpose Uric acid (UA) plays a dual role as an antioxidant and a prooxidant in patients with
malignant tumors; however, the relationship between serum UA and malignancy is currently …

Elevated urinary 8-oxo-7, 8-dihydro-2′-deoxyguanosine and serum uric acid are associated with progression and are prognostic factors of colorectal cancer

L Mao, C Guo, S Zheng - OncoTargets and therapy, 2018 - Taylor & Francis
Background and purpose Oxidative stress is closely related to the pathogenesis of colorectal
cancer (CRC). 8-Oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxodG) is a typical bio-marker of …

The potential of aryl hydrocarbon receptor as receptors for metabolic changes in tumors

Z Wang, Y Zhang, Z Liao, M Huang, X Shui - Frontiers in Oncology, 2024 - frontiersin.org
Cancer cells can alter their metabolism to meet energy and molecular requirements due to
unfavorable environments with oxygen and nutritional deficiencies. Therefore, metabolic …