Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide

B Nucera, F Brigo, E Trinka… - Therapeutic advances in …, 2022 - journals.sagepub.com
Women with epilepsy (WWE) wishing for a child represent a highly relevant subgroup of
epilepsy patients. The treating epileptologist needs to delineate the epilepsy syndrome and …

Neurodevelopmental outcomes in children exposed to newer antiseizure medications: A systematic review

R Knight, A Wittkowski, RL Bromley - Epilepsia, 2021 - Wiley Online Library
As prenatal exposure to certain older antiseizure medications (ASMs) has been linked with
poorer neurodevelopmental outcomes in children, the use of newer ASMs throughout …

The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an …

A Marson, G Burnside, R Appleton, D Smith, JP Leach… - The Lancet, 2021 - thelancet.com
Background Valproate is a first-line treatment for patients with newly diagnosed idiopathic
generalised or difficult to classify epilepsy, but not for women of child-bearing potential …

Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism

J Christensen, TK Grønborg, MJ Sørensen, D Schendel… - Jama, 2013 - jamanetwork.com
Importance Valproate is used for the treatment of epilepsy and other neuropsychological
disorders and may be the only treatment option for women of childbearing potential …

Two-year-old cognitive outcomes in children of pregnant women with epilepsy in the maternal outcomes and neurodevelopmental effects of antiepileptic drugs study

KJ Meador, MJ Cohen, DW Loring, RC May… - JAMA …, 2021 - jamanetwork.com
Importance The neurodevelopmental risks of fetal exposure are uncertain for many
antiseizure medications (ASMs). Objective To compare children at 2 years of age who were …

[HTML][HTML] Prenatal exposure to benzodiazepines and Z-drugs in humans and risk of adverse neurodevelopmental outcomes in offspring: A systematic review

X Wang, T Zhang, I Ekheden, Z Chang… - Neuroscience & …, 2022 - Elsevier
When used during pregnancy, benzodiazepines (BZDs) and related z-drugs could pass
readily through the placenta and the foetal blood-brain barrier, where they can bind to γ …

Behavioral outcomes and neurodevelopmental disorders among children of women with epilepsy

MJ Cohen, KJ Meador, DW Loring, AG Matthews… - JAMA …, 2024 - jamanetwork.com
Importance The association of fetal exposure to antiseizure medications (ASMs) with
outcomes in childhood are not well delineated. Objective To examine the association of fetal …

Management of epilepsy during pregnancy and lactation

OA Hope, KMJ Harris - bmj, 2023 - bmj.com
Epilepsy is a group of neurological diseases characterized by susceptibility to recurrent
seizures. Antiseizure medications (ASMs) are the mainstay of treatment, but many …

Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non …

AG Marson, G Burnside, R Appleton… - Health Technology …, 2021 - research.bangor.ac.uk
The aims of the SANAD II trial were to assess the longer-term clinical effectiveness and
costeffectiveness of levetiracetam and zonisamide compared with lamotrigine in focal …

Update on sudden unexpected death in epilepsy

M Kløvgaard, A Sabers, P Ryvlin - Neurologic Clinics, 2022 - neurologic.theclinics.com
Persons with epilepsy (PWE) have a high risk of premature death with a two to fourfold
increased standardized mortality ratios (SMR) compared with the background population. 1 …