[HTML][HTML] Nose-to-brain delivery of therapeutic peptides as nasal aerosols
Central nervous system (CNS) disorders, such as psychiatric disorders, neurodegeneration,
chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would …
chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would …
Brain targeting of duloxetine HCL via intranasal delivery of loaded cubosomal gel: in vitro characterization, ex vivo permeation, and in vivo biodistribution studies
FM Elsenosy, GA Abdelbary, AH Elshafeey… - International journal …, 2020 - Taylor & Francis
Purpose Duloxetine (DLX) is dual serotonin and norepinephrine reuptake inhibitor suffering
from limited bioavailability (≈ 40%) due to extensive hepatic metabolism. This work aims to …
from limited bioavailability (≈ 40%) due to extensive hepatic metabolism. This work aims to …
[HTML][HTML] Intranasal delivery of granisetron to the brain via nanostructured cubosomes-based in situ gel for improved management of chemotherapy-induced emesis
This research aimed to boost granisetron (GS) delivery to the brain via the intranasal route to
better manage chemotherapy-induced emesis. Glycerol monooleate (GMO), Poloxamer 407 …
better manage chemotherapy-induced emesis. Glycerol monooleate (GMO), Poloxamer 407 …
[HTML][HTML] Sesame oil-based nanostructured lipid carriers of nicergoline, intranasal delivery system for brain targeting of synergistic cerebrovascular protection
MAS Abourehab, A Khames, S Genedy, S Mostafa… - Pharmaceutics, 2021 - mdpi.com
Nicergoline (NIC) is a semisynthetic ergot alkaloid derivative applied for treatment of
dementia and other cerebrovascular disorders. The efficacy of sesame oil to slow and …
dementia and other cerebrovascular disorders. The efficacy of sesame oil to slow and …
Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy
AM Mohsen, AAA Salama… - Pharmaceutical …, 2023 - Taylor & Francis
Lamotrigine (LTG) is a second-generation antiepileptic drug that belongs to
Biopharmaceutics Classification System (BCS) class II. LTG has a low probability of crossing …
Biopharmaceutics Classification System (BCS) class II. LTG has a low probability of crossing …
[HTML][HTML] Verapamil-Loaded Cubosomes for Enhancing Intranasal Drug Delivery: Development, Characterization, Ex Vivo Permeation, and Brain Biodistribution …
Verapamil hydrochloride (VRP), an antihypertensive calcium channel blocker drug has
limited bioavailability and short half-life when taken orally. The present study was aimed at …
limited bioavailability and short half-life when taken orally. The present study was aimed at …
[PDF][PDF] Nose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols. Pharmaceutics 2022, 14, 1870
W Alabsi, BB Eedara, D Encinas-Basurto, R Polt… - 2022 - academia.edu
Central nervous system (CNS) disorders, such as psychiatric disorders, neurodegeneration,
chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would …
chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would …
Synthesis, Comprehensive Characterization, and Development of Therapeutic Peptides and Glycopeptides for Targeted Respiratory Drug Delivery as Inhalation …
W Alabsi - 2021 - search.proquest.com
Central nervous system (CNS) disorders, including neurodegeneration and chronic pain,
and many respiratory diseases would greatly benefit from the specific and potent peptide …
and many respiratory diseases would greatly benefit from the specific and potent peptide …