The World Health Organization (WHO) warns that physical inactivity increases the number of
global public health problems, such as the risk of non-communicable diseases (eg …

Human survival and wellbeing require appropriate responses to stress, including a highly
coordinated and efficient nervous system control of the heart rhythm. During stress, a greater …

Background It is unknown whether lowered steady state levels of sex hormones coupled
with changes in those hormones during the menstrual cycle are associated with …

Mood and anxiety disorders are vastly overrepresented in women, and one important
contributor to these differences is the fluctuation in sex steroids in women during the …

There is increasing recognition that women have a higher prevalence of certain psychiatric
illnesses, and a differential treatment response and course of illness compared to men …

There is a consensus that the development of premenstrual dysphoric states is related to
cyclical change in gonadal hormone secretion during the menstrual cycle. However, results …

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) encompass a
variety of symptoms that occur during the luteal phase of the menstrual cycle and impair …

Objective Transgender women take gender-affirming hormone therapy (GAHT) to affirm their
gender identity and improve quality of life and well-being. Usually, GAHT in transgender …

AC-5216, a ligand for the translocator protein (18 kDa)(TSPO), previously called the
peripheral benzodiazepine receptor (PBR), produces anxiolytic-like effects mediated by …

Animal studies suggest that neuroactive steroids, in particular progesterone and its
metabolites, have stress-dampening effects. However, few studies have explored these …