Certain women experience negative mood symptoms during the menstrual cycle and
progesterone addition in estrogen treatments. In women with PMDD increased negative …

Objective: Premenstrual dysphoric disorder (PMDD) is a common mood disorder,
characterized by distressing affective, behavioral, and somatic symptoms in the late luteal …

Gonadal hormones are known to influence the regulation of emotional responses and
affective states. Whereas fluctuations in progesterone and estradiol are associated with …

The acute neural effects of progesterone are mediated by its neuroactive metabolites
allopregnanolone and pregnanolone. These neurosteroids potentiate the inhibitory actions …

Women with premenstrual dysphoric disorder (PMDD) experience mood symptoms related
to the increase in progesterone and the neuroactive steroid allopregnanolone. Our …

Context Allopregnanolone is a metabolite from progesterone and a positive modulator of the
GABA A receptor. This endogenous steroid may induce negative mood in sensitive women …

Neurosteroids represent a class of endogenous steroids that are synthesized in the brain,
the adrenals, and the gonads and have potent and selective effects on the GABAA-receptor …

Certain women experience negative mood symptoms as a result of progesterone during the
luteal phase of the menstrual cycle, progestagens in hormonal contraceptives, or the …

Hormonal fluctuations across the menstrual cycle are thought to play a central role in
premenstrual mood symptoms. In agreement, fluctuations in gonadal hormone levels affect …

Some women have negative mood symptoms, caused by progestagens in hormonal
contraceptives or sequential hormone therapy or by progesterone in the luteal phase of the …