DNA methylation, an epigenetic modification, regulates gene transcription and maintains
genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at …

Both genetic and epigenetic changes contribute to development of human cancer.
Oncogenomics has primarily focused on understanding the genetic basis of neoplasia, with …

Background Breast cancer formation is associated with frequent changes in DNA
methylation but the extent of very early alterations in DNA methylation and the biological …

Purpose: By hypomethylating genes, decitabine may up-regulate factors required for
chemotherapeutic cytotoxicity. Platinum-resistant cells may have reduced expression of the …

The long noncoding RNA (lncRNA) TINCR has recently been found to be associated with
the progression of human malignancies, but the molecular mechanism of TINCR action …

Purpose Regulation of epidermal growth factor receptor (EGFR) signaling pathways may
play a relevant role in determining the activity of cetuximab therapy in patients with …

Background: The role of epidermal growth factor receptor (EGFR) has been established in a
range of neoplasms. In melanoma, data on EGFR protein expression are conflicting …

Cigarette smoking (CS) exposure-induced airway inflammatory responses drive the
occurrence and development of emphysema and chronic obstructive pulmonary disease …

A core set of oncoproteins is overexpressed or functionally activated in many types of
cancer, and members of this group have attracted significant interest as subjects for …

Copy number alterations of the epidermal growth factor receptor (EGFR) gene have been
extensively analyzed in different cancers, but no data are available for primary malignant …