Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia,
dental pain, and debilitating headaches, affects millions of Americans each year with …

Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cationic channel
activated by painful stimuli such as capsaicin and noxious heat, and enriched in sensory …

Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors, but
rodent models of pain-related OA have concentrated on allodynia rather than ongoing pain …

Pain measures traditionally used in rodents record mere reflexes evoked by sensory stimuli;
the results thus may not fully reflect the human pain phenotype. Alterations in physical and …

Temporomandibular disorder (TMD) pain that involves inflammation and injury in the
temporomandibular joint (TMJ) and/or masticatory muscle is the most common form of …

Temporomandibular disorders (TMD) represent a group of musculoskeletal conditions
involving the temporomandibular joints (TMJ), the masticatory muscles and associated …

In the 1990s, the identification of a non-selective ion channel, especially responsive to
capsaicin, revolutionized the studies of somatosensation and pain that were to follow. The …

Simple Summary The Mouse Grimace Scale (MGS) was developed as a tool for the
measurement of pain in laboratory mice. There have been a number of studies focused on …

Craniofacial muscle pain is highly prevalent in temporomandibular disorders but is difficult to
treat. Enhanced understanding of neurobiology unique to craniofacial muscle pain should …