ATP-binding cassette (ABC) transporters constitute one of the largest and most ancient
protein superfamilies found in all living organisms. They function as molecular machines by …

Bacterial pathogens as causative agents of infection constitute an alarming concern in the
public health sector. In particular, bacteria with resistance to multiple antimicrobial agents …

Single-molecule Förster-resonance energy transfer (smFRET) experiments allow the study
of biomolecular structure and dynamics in vitro and in vivo. We performed an international …

Soil microorganisms act as gatekeepers for soil–atmosphere carbon exchange by balancing
the accumulation and release of soil organic matter. However, poor understanding of the …

Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …

The land-use change from natural to managed farmland ecosystems can undergo
perturbations and significantly impact soil environment and communities. To understand …

Heavy metal contamination poses a serious environmental hazard, globally necessitating
intricate attention. Heavy metals can cause deleterious health hazards to humans and other …

Members of the genus Bifidobacterium are among the first microbes to colonize the human
gastrointestinal tract and are believed to exert positive health benefits on their host. Due to …

ABC transporters catalyze transport reactions, such as the high-affinity uptake of
micronutrients into bacteria and the export of cytotoxic compounds from mammalian cells …

Multidrug resistance is a key determinant of cancer chemotherapy failure. One of the major
causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC …