Targeted protein degradation (TPD) aids in developing novel bifunctional small-molecule
degraders and eliminates proteins of interest. The TPD approach shows promising results in …

Simple Summary Successful gene therapy mainly depends on the fabrication of efficient and
nontoxic carriers that can compact genetic materials and adequately deliver them to target …

ABSTRACT Introduction PROteolysis-TArgeting Chimeras (PROTACs) allow the selective
degradation of a protein of interest (POI) by the ubiquitin-proteasome system (UPS). With …

Targeted protein degradation is an attractive technology for cancer treatment due to its
ability to overcome the unpredictability of the small molecule inhibitors that cause resistance …

Background: Hepatocellular carcinoma (HCC) is the sixth incidence of cancer and the third
leading cause of cancer mortality in the world. Facing the ever-increasing population of HCC …

Leukemia is a heterogeneous group of life‐threatening malignant disorders of the
hematopoietic system. Immunotherapy, radiotherapy, stem cell transplantation, targeted …

Multiple myeloma (MM) is a hematological malignancy characterized by the dysregulated
proliferation of transformed plasma cells (PCs) primarily in the bone marrow (BM)(1). For the …

The transition of a linear polypeptide chain into a functional, 3-dimensional protein is fraught
with dangers, but a successful outcome is critical to all aspects of life. To assist and monitor …

Gold nanoparticles (AuNPs) have gained increasing attention as novel drug-delivery
nanostructures for the treatment of cancers, infections, inflammations, and other diseases …