Neutrophils derive from hematopoietic stem cells (HSCs) with systemic inflammation driving
their activation and differentiation to myeloid progenitors to ensure enhanced myelopoiesis …

Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and
hyperreactivity of the immune response at various levels, including hyperactivation of …

Th17 cells are most abundant in the gut, where their presence depends on the intestinal
microbiota. Here, we examined whether intestinal Th17 cells contribute to extra-intestinal …

Excessive cytokine activity underlies many autoimmune conditions, particularly through the
interleukin-17 (IL-17) and tumor necrosis factor–α (TNFα) signaling axis. Both cytokines …

Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-
17F. IL-17 family cytokines play a key role in host defense responses and inflammatory …

Glomerulonephritis is traditionally considered to result from the invasion of the kidney by
autoantibodies and immune complexes from the circulation or following their formation in …

Systemic lupus erythematosus (SLE) is a very complex disease where multiple
immunological pathways can concur in inducing tissue damage. Cytokines are key …

Unconventional T cells are a diverse and underappreciated group of relatively rare
lymphocytes that are distinct from conventional CD4+ and CD8+ T cells, and that mainly …

Glomerulonephritis (GN) comprises a group of immune-mediated kidney diseases affecting
glomeruli and the tubulointerstitium. Glomerular crescent formation is a histopathological …

CD4+ T cells are important drivers of tissue damage in immune-mediated renal diseases,
such as anti-glomerular basement membrane glomerulonephritis, anti-neutrophil …