With the growing demand for clinically reliable therapeutics, traditional small molecule drugs
are increasingly limited by their short circulation duration, low bioavailability, and poor …

For the longest time, the field of nucleic acid delivery has remained skeptical whether or not
polycationic drug carrier systems would ever make it into clinical practice. Yet, with the …

Protein drugs targeting intracellular machineries have shown profound therapeutic
potentials, but their clinical utilities are greatly hampered by the lack of efficient cytosolic …

Polymers have been widely proposed as carriers for cytosolic protein delivery despite
multiple barriers such as protein binding, cell internalization, and endosome escape during …

Abstract Changes in sub-cellular pH play a key role in metabolism, membrane transport, and
triggering cargo release from therapeutic delivery systems. Most methods to measure pH …

Due to membrane impermeability of proteins, intracellular delivery of protein is of significant
challenge. Although numerous protein carriers have been reported, it remains difficult to …

All nanoparticles have the potential to revolutionize the delivery of therapeutic cargo such as
peptides, proteins, and RNA. However, effective cytosolic delivery of cargo from …

Developing a universal nanoplatform for efficient delivery of various drugs to target sites is
urgent for overcoming various biological barriers and realizing combinational cancer …

Current strategies for the delivery of proteins into cells face general challenges of
endosomal entrapment and concomitant degradation of protein cargo. Efficient delivery …

Pyroptosis is a new type of regulated cell death that is of great interest for developing new
strategies for treating cancers. This potential is however greatly limited by the low efficiency …