[PDF][PDF] The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

AA Cluntun, R Badolia, S Lettlova, KM Parnell… - Cell metabolism, 2021 - cell.com
The metabolic rewiring of cardiomyocytes is a widely accepted hallmark of heart failure (HF).
These metabolic changes include a decrease in mitochondrial pyruvate oxidation and an …

Prevalence and prognostic significance of left ventricular reverse remodeling in dilated cardiomyopathy receiving tailored medical treatment

M Merlo, SA Pyxaras, B Pinamonti, G Barbati… - Journal of the American …, 2011 - jacc.org
Objectives: The purpose of this study was to determine the prevalence and prognostic role of
left ventricular reverse remodeling (LVRR) in idiopathic dilated cardiomyopathy (IDCM) …

Carvedilol: a review of its use in chronic heart failure

GM Keating, B Jarvis - Drugs, 2003 - Springer
Carvedilol (Dilatrend®) blocks β 1-, β 2-and α 1-adrenoceptors, and has antioxidant and
antiproliferative effects. Carvedilol improved left ventricular ejection fraction (LVEF) in …

Drugs for left ventricular remodeling in heart failure

M Frigerio, E Roubina - The American journal of cardiology, 2005 - Elsevier
Left ventricular (LV) remodeling (ie, enlargement and functional deterioration occurring over
time) is among the main mechanisms of progression in heart failure (HF). LV dilatation and …

Genetic predictors and remodeling of dilated cardiomyopathy in muscular dystrophy

JL Jefferies, BW Eidem, JW Belmont, WJ Craigen… - Circulation, 2005 - Am Heart Assoc
Background—Dystrophin gene mutations cause 2 common muscular dystrophies,
Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Both are …

Early identification of left ventricular remodelling after myocardial infarction, assessed by transthoracic 3D echocardiography

HFJ Mannaerts, JA van der Heide, O Kamp… - European heart …, 2004 - academic.oup.com
Aims The usefulness of 3D echocardiography (3DE) for accurate evaluation of left
ventricular (LV) remodelling after acute myocardial infarction (AMI), and early identification …

Increased exercise ejection fraction and reversed remodeling after long‐term treatment with metoprolol in congestive heart failure: a randomized, stratified, double …

F Waagstein, O Strömblad, B Andersson… - European Journal of …, 2003 - Wiley Online Library
Background: the effects of long‐term administration of β‐blockers on left ventricular (LV)
function during exercise in patients with ischemic heart disease (IHD) and idiopathic dilated …

Left ventricular reverse remodelling and its predictors in non‐ischaemic cardiomyopathy

T Hnat, J Veselka, J Honek - ESC Heart Failure, 2022 - Wiley Online Library
Adverse remodelling following an initial insult is the hallmark of heart failure (HF)
development and progression. It is manifested as changes in size, shape, and function of the …

Ventricular remodeling in heart failure

MA Gaballa, S Goldman - Journal of cardiac failure, 2002 - Elsevier
This review briefly highlights the major mechanisms of left ventricular (LV) remodeling
following myocardial infarction in heart failure and presents novel strategies to limit infarct …

Use of carvedilol in hypertension: an update

G Leonetti, CG Egan - Vascular Health and Risk Management, 2012 - Taylor & Francis
β-blockers are effective antihypertensive agents and, together with diuretics, have been the
cornerstone of pioneering studies showing their benefits on cardiovascular morbidity and …