The hypertrophic response to overload plays an important role in the progressive
deterioration of the failing heart—the “Cardiomyopathy of Overload”—and so contributes to …

Background Cardiac resynchronization therapy (CRT) is associated with improved morbidity
and mortality in patients with chronic heart failure (CHF) on optimal medical therapy. The …

Abstract β-Adrenergic receptor (AR) blockers provide substantial clinical benefits, including
improving overall survival and left ventricular (LV) function following myocardial infarction …

Maladaptive remodeling is associated with impaired prognosis in heart failure, and
prevention of remodeling is an established therapeutic target. However, it is much less clear …

Background: The ability of β blockers to improve left ventricular function has been
demonstrated, but data on the effects on cardiac remodelling are limited. Objective: To …

Aim Peripheral vasoconstriction has long been described as a vascular adverse effect of β‐
adrenoceptor blockers. Whether β‐adrenoceptor blockers should be avoided in patients with …

Heart failure has traditionally been viewed as a hemodynamic syndrome characterized by
fluid retention, high venous pressure, and low cardiac output. Over the past decade …

Therapy for heart failure has traditionally been directed to such short-term functional
abnormalities as low cardiac output, high filling pressures, and fluid retention. More recently …

Background: In adults with heart failure, neurohormonal overstimulation is related to the
progression of the disease, and influences prognosis. β-blockers, which modulate …

Background—There are limited data regarding factors associated with spontaneous left
ventricular reverse remodeling (S-LVRR) among mildly symptomatic heart failure (HF) …