Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Peroxisomes are membrane-bound organelles involved in many metabolic pathways and
essential for human health. They harbor a large number of enzymes involved in the different …

The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types
of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each …

Stop-codon read-through refers to the phenomenon that a ribosome goes past the stop
codon and continues translating into the otherwise untranslated region (UTR) of a transcript …

Reduced (NADH) and oxidized (NAD+) nicotinamide adenine dinucleotides are ubiquitous
hydride-donating/accepting cofactors that are essential for cellular bioenergetics …

In most eukaryotes and prokaryotes TGA is used at a significantly higher frequency than
TAG as termination codon of protein-coding genes. Although this phenomenon has been …

Recognition of a stop codon by translation machinery as a sense codon results in
translational readthrough instead of termination. This recoding process, termed stop codon …

A stop codon entering the ribosome A-site is normally decoded by release factors that
induce release of the polypeptide. Certain factors influence the efficiency of the termination …

Alternative translation initiation and stop codon readthrough in a few well-studied cases
have been shown to allow the same transcript to generate multiple protein variants. Because …

Translation of mRNA into a polypeptide is terminated when the release factor eRF1
recognizes a UAA, UAG, or UGA stop codon in the ribosomal A site and stimulates nascent …