In the last two decades, there has been growing interest in mRNA-based technology for the
development of prophylactic vaccines against infectious diseases. Technological …

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for a
recent, unexpectedly severe epidemic in countries of the Indian Ocean region. Although …

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a
disease characterized by fever, rash, and pain in muscles and joints. The recent emergence …

This review provides a detailed look at the attributes and immunologic mechanisms of
plasmid DNA vaccines and their utility as laboratory tools as well as potential human …

An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in
countries of the Indian Ocean area, causing an acute and painful syndrome with strong …

A variety of both RNA and DNA viruses envelop their capsids in a lipid bilayer. One of the
more recently appreciated benefits this envelope is incorporation of phosphatidylserine …

ABSTRACT C-type lectins such as DC-SIGN and L-SIGN, which bind mannose-enriched
carbohydrate modifications of host and pathogen proteins, have been shown to bind …

Mucosal immunisation may be used both to prevent mucosal infections through the
activation of anti-microbial immunity and to treat selected autoimmune, allergic or infectious …

Alphaviruses productively infect a variety of vertebrate and insect cell lines. In vertebrate
cells, Sindbis virus redirects cellular processes to meet the needs of virus propagation. At …

Alphavirus replicon particle-based vaccine vectors derived from Sindbis virus (SIN), Semliki
Forest virus, and Venezuelan equine encephalitis virus (VEE) have been shown to induce …